CBD for Sleep: The Sleep Benefits Of CBD Oil

CBD oil plays a very interesting role in sleep… and it’s NOT what you might think. There are a lot of “bloggers” out there right now touting that CBD and hemp extract are great for helping you sleep well. However, that is not the total truth.

CBD is indirectly responsible for better sleep mostly because CBD stops inflammation on the cellular level. As a potent antioxidant, it keeps free radical stress in check. This can definitely improve the quality and restfulness of your sleep.

However, the CBD molecule itself has actually been found in the medical research to induce wakefulness… quite the opposite of sleep.

I will show you these studies today.

A basic understanding of the role that CBD plays in the sleep-wake cycle will help you to make the right decision about what time of day to take your CBD supplement.

What Is CBD?

If you’re new here to TheUniversalPlant.com then, maybe you just landed here from a Google search for example, and maybe you don’t quite know exactly what CBD is, then I highly recommend you start off by reading this article so you understand the basics.

CBD is a cannabinoid, known as cannabidiol, that is found in both hemp and marijuana.

It has many amazing therapeutic benefits for human health, many of which I’ve written about in detail on this blog. If you’re interested in learning the healing secrets locked inside the hemp plant, check out our pillar article on how to use hemp as medicine.

CBD Oil and Sleep: The Research

Let’s take a look at what the science has to say about how CBD may help improve your sleep.

To summarize, before we dive into the details, the following appears to be true:

  • CBD may help reduce anxiety,1 which is a major cause of insomnia
  • CBD induces alertness,2 but also appears to help increase overall sleep time at night3
  • CBD helps with sleep onset in pain patients4
  • CBD correlates with less dream recall5
  • CBD may help reduce insomnia5
  • CBD’s alertness promoting property is powerful enough to counteract the sedative properties of the same dose of THC6
  • CBD may help improve REM Sleep Disorder7

CBD and Anxiety

Anxiety is an interesting beast. Most of us suffer from differing levels of anxiety at one time or another in life, but some individuals cannot seem to shake it, developing deep anxiety issues that negatively affect their life, and can even lead to insomnia where they are tossing and turning all night long, unable to fall asleep or stay asleep.

CBD has show some promise in the research for helping to reduce symptoms of anxiety.1 The endocannabinoid system may play a very important role in regulating emotion and emotional memory processing, and is quickly becoming an exciting area of research for behavioral neuroscientists.

CBD as an Alertness Promoting Agent

Across the board, it would appear as though CBD is a natural wakefulness promoting compound. Because of this, it seems smart to recommend to take your CBD supplement or full spectrum hemp extract supplement in the morning, so as to keep you alert all day and not interfere with falling asleep.

Interestingly enough, when subjects do this, it appears that not only do they stay alert and awake throughout the day, but they also fall asleep at night more quickly (without any additional sleep aids) and stay asleep longer (see the research referenced above).

This would appear to be because CBD is known to modulate the microglia activation of the inflammatory cycle, keeping your body in a less-inflamed state and lowering your stress.

CBD May Improve Sleep Onset

In this review of studies done on chronic pain patients, which I definitely recommend reading in its entirety if you’re interested in the subject of pain and cbd or pain and hemp extract, the reviewer found adequate evidence to correlate CBD oil consumption with improving multiple sleep biomarkers including sleep onset, which is basically how quickly someone falls asleep.

cbd sleep onset
Table summarizing cannabis applications for pain and sleep

CBD Correlates with Less Dream Recall, Reduction In Insomnia

This study5 saw a repeating incidence of lower dream recall in CBD subjects, which is very interesting. It’s difficult to point to a mechanism here since very little is known about the nature of dreams still in the field of neuroscience. However, this does point to the idea that dream recall may be regulated by the endocannabinoid system to some degree.

That same study also saw a decrease in insomnia symptoms amongst subjects.

Conclusion on CBD Oil and Sleep Parameters

To sum things up nicely with regards to the subject, it appears as though CBD, cannabidiol, is positively correlated with improving sleep parameters, but funny enough… NOT by actually making you sleepy, as it is a wakefulness promoting agent and not a sedative like THC.

In fact, it appears to promote sleep improvements due to the fact that it can lower stress levels as a powerful antioxidant, where it’s benefits with controlling free radical induced inflammation are well-documented. This is great news, as you can consume your CBD supplements in the morning to keep you stress-free and relaxed, but focused, throughout the day, then you may fall asleep more quickly and stay asleep longer throughout the night.

For help sleeping, we recommend a product with melatonin in it. CBDistillery offers a nighttime gummie that’s perfect for sleep issues.

If you want to learn about more recommended retailers, check out our page on Where To Buy CBD.

Medical References

Lee J, Bertoglio L, Guimarães F, Stevenson C. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. Br J Pharmacol. 2017;174(19):3242-3256. [PubMed]
Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R. The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. Behav Neurosci. 2008;122(6):1378-1382. [PubMed]
Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett. 2006;580(18):4337-4345. [PubMed]
Evans H, Taylor J, Ernst J, Graefe J. Methods to evaluate the wellbeing of laboratory primates: comparisons of macaques and tamarins. Lab Anim Sci. 1989;39(4):318-323. [PubMed]
Carlini E, Cunha J. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol. 1981;21(8-9 Suppl):417S-427S. [PubMed]
Nicholson A, Turner C, Stone B, Robson P. Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305-313. [PubMed]
Chagas M, Eckeli A, Zuardi A, et al. Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series. J Clin Pharm Ther. 2014;39(5):564-566. [PubMed]

Where To Buy CBD Oil and Hemp Extract

It can be difficult to find decent options for where to buy CBD oil and hemp extract, so I figured I’d put together a page here that helps you identify the best ones to buy for your specific purposes of helping fight inflammation, lower stress, improving sleep, and other issues.

The US government definitely does not make it easy to buy hemp extract and CBD oil, as they’re totally in bed with Big Pharma at this point, and continue to outlaw most forms of natural plant medicine that the general public is looking for. So finding good product can be a challenge.

I’ve compiled some options for you here on this page, but I’m not sure how long they will be available. So I will continue to update this page as I find more options, or as companies get shut down by the government. If you’re curious, I recommend jumping on this soon, as these companies also offer money-back guarantees like good companies should, so there’s no risk on your part.

I’ve checked all these sites too, and they use totally secure checkout processes which protect us from hackers.

What Is Hemp Extract?

Hemp extract is the full spectrum oil extracted from the seeds and stalks of industrial hemp plants. The full spectrum hemp oil typically contains not just CBD but also a host of other awesome benefits from the terpenes and a range of different cannabinoids, as well as the antioxidant benefits from Vitamin E and other vitamins and minerals contained naturally in hemp.

I personally think it’s very important to use a hemp extract that has the Vitamin E intact since high amounts of Polyunsaturated fat consumption has been linked to hormonal health issues. The presence of natural Vitamin E in the hemp actually helps to negate any of these bad effects, making the whole plant extract more valuable and healthier to consume regularly.

What Is CBD Oil?

CBD oil is otherwise known as cannabidiol, and is derived from the hemp plant. It is what is known as a cannabinoid, and it acts to indirectly activate the human body’s endocannabinoid system, leading to a host of positive health benefits, specifically around inflammation, since it has been shown in human research to help regulate the body’s microglial activation of the immune system via pro-inflammatory cytokines. CBD oil seems to regulate this response really well as a potent antioxidant. So now let’s take a look at where to buy cbd.

Where Do You Buy Hemp Extract And CBD Oil?

Okay so by now you’re probably wondering where you can get your hands on some good full spectrum hemp extract and CBD oil. I’ve outlined a few good options for you here below this page.

CBDPure Full Spectrum Hemp Extract 100mg Tincture

CBDPure has a solid range of tincture products available, from 100mg to 600mg per serving. The 100mg serving is a great, affordable option for anyone who is just curious about CBD and hemp extract, and maybe experiencing some anxiety issues and just wants something they can take daily to relax. You can find the 100mg CBDPure hemp extract here.


where to buy cbdCBDPure Full Spectrum Hemp Extract 300mg Liquid

The 300mg extract is a bit stronger than the 100mg, so I’d recommend this option for anyone with the following issues:

  • Mild pain or inflammation of the skin
  • Digestive issues
  • Sleeping problems and insomnia
  • A high stress career
  • Frequent traveling
  • Depression

If you’re interested in this CBDPure 300mg hemp extract, you can find it here on this secure website.

cbd pure hemp extractCBDPure Full Spectrum High Potency Hemp Extract 600mg Tincture

The 600mg liquid is twice as strong as the 300mg one, so for this one I recommend this for anyone who really needs anti-inflammatory help with more serious issues, or maybe wants to overcome their health issues more quickly than if you were to use the 300mg hemp extract.

This could also be a way to take less liquid but also get a very potent amount, since sometimes taking a lot of the oil can cause stomach upset.

You can find the CBD Pure hemp extract 600mg liquid here.


Additional Options for CBD Oil and Hemp Extract

I’ve also found some good options on other variations of CBD. These are my favorites options, from tinctures, to capsules, to even gummies 😉

Hemp Bombs CBD Gummies High Potency

These gummies are delicious are some of the best on the market right now in terms of high CBD content and good pricing.

Here’s an example of one of the good reviews for Hemp Bombs CBD Gummies HP:

Worked Well On My Stress and Anxiety

“I am a single father of 3 teenagers and financially I do ok but don’t make a whole lot of money. I’m telling you this because with kids and money issues I got a lot of pressure and stress on me and have for at least the past 8 years. The kind that keeps you up at night worrying, sometimes so overwhelming that you have paralyzing panic attacks or just break out in a “I don’t know what the F to do” sweat… Oh. my kids are all teenagers so just imagine that.

I recently started taking these gummies daily, I’m at 2 gummies and that seems to be working best for me. So the good news for me is that my stress and anxiety are gone. Sounds unbelievable. The change is subtle came on with out me noticing it, with no big Boom or Wow, just realized “Hey, I’m not freaking out, I’m not overwhelmed, I’m sleeping better, I can focus on the issues and problems in my life and work on solutions..

I know that anxiety is real and mine was real, not crushing or stopping me but always there. Now its not.”

Hemp Bombs CBD Gummies

If you’re looking for a lower dose of CBD per gummy than the HP version above, Hemp Bombs also has a lot of options in terms of regular CBD gummies too. You can see all of the options on the Gummies page.

Buy Hemp Bombs CBD Gummies Here

Helps with pain, without the high.

“Helps with pain without the high. Had to lay down because of debilitating back pain. Took my CBD gummies & laid down on the sofa. A little later had to get up to the restroom and was all the way to the restroom door before I was aware that I had NO pain. Just what I was looking for, pain relief without sedation. Thank you Hemp Bombs.”

And this one for MS.

Helps MS Symptoms!

“First I’m not a medical professional and this is Not medical advice.

I am 39 and have been diagnosed with multiple sclerosis (MS) since 2010. Some of my symptoms are vertigo, dizziness, nerve pain in my ear, muscle spasms, and restless leg syndrome (RLS.) I live in a state where medical and recreational marijuana are both legal. Medical marijuana is said to help nerve pain and muscle spasms in MS. My problem however is that if it has any THC my vertigo and dizziness become severe and debilitating. Enter CBD gummies. No THC but all the healing parts of the plant! After just one use, my nerve pain and muscle spasms were cut in half within 10 minutes. That day I used another gummy before bed and, wait for it…….No RLS issues! I could actually lay in bed and Not have my legs kick around or have any of the itchy/tingling feelings that come with RLS. I was actually able to sleep! My MS neurologist has prescribed about 6 different medications trying to help me with these symptoms with no luck. She even prescribed medical marijuana but I couldn’t handle it because of the dizziness and vertigo it caused. I won’t say that this oil cures anything But it does make my life Much more Comfortable! I can actually get a good night sleep because my legs are finally still, it’s wonderful. I’m almost brought to tears.



Hopefully this list is helpful for starting out on your hemp journey.

Please let me know in the comments below if you find some other good options and I can update this to include them on this list of places to buy hemp and cbd oil.

CBD and Inflammation: The Anti-Inflammatory Benefits Of Hemp Oil

In this post I’m going to outline the collective body of current research on CBD and Hemp Extract with relation to Inflammation. There is a decent amount of research to this point, all indicating pretty impressive benefits of CBD for inflammation, typically looking at inflammation biomarkers (indicators) and positive improvements when subjects use CBD or Hemp Extract over the control groups. CBD oil for inflammation is becoming increasingly more common as awareness around cannabis increases.

The body of research will no doubt continue to grow as more funding pours into this space, and as public interest continues to rise. Also, when cannabis becomes federally legal in the United States, then we will really see a large influx of research funding into the therapeutic uses of the plant.

Research around the compounds in this plant for inflammation reduction is especially important because inflammation is basically a bodily state that correlates to many life-threatening diseases. Many people’s lives can be saved through proper prevention measures, and for those individuals who are deep into their issues with inflammation, they may be able to turn things around before it is too late.

What Is Inflammation?

Before we dive into the research around CBD and Hemp and Inflammation, I think it’s appropriate to actually define what inflammation truly is. Armed with this basic understanding, you’ll more firmly grasp the results of the studies I’m going to present to you today.

Inflammation is a bodily response to harmful stimuli.

Many things can cause this response in your body, which is why inflammation is more of what I would consider a “warning sign” rather than a disease itself. Like I mentioned earlier, because it is a warning sign it typically correlates with many different diseases in humans.

The major easy-to-spot signs that you have inflammation issues are: pain, swelling, soreness, fatigue, itchy skin, redness, heat, and even gut issues like Ulcerative Colitis, IBS, and diarrhea.

Inflammation is basically a generic response to a threat to your health. Your body activates your immune system as you try to fight off the “attacker.” Unfortunately for most people, their habits are what causes the inflammation in the first place.

They are attacking themselves!

Bad habits like poor diet, micronutrient deficiencies, excess stress, and constant exposure to endocrine disrupting chemicals like those found in plastics, smog in the air, and even many foods, are constantly bombarding our bodies every single day, and unless you are aware of them, you’re essentially just reinforcing their attack on your body.

It’s no wonder inflammation is such a common thing these days, and autoimmune diseases are increasing in number every single year. We are quite literally enabling this to happen to ourselves. And unless we wake up to this reality, it will continue to happen.


Cannabidiol As An Emergent Inflammation Therapy

Inflammation has traditionally been a tricky nail to hammer for researchers when it comes to finding a therapeutic solution. The most promising area of study has involved the endocannabinoid system, namely CB1 and CB2 receptor activation which are G-protein-coupled receptor sites and the ligands that activate them.

Cannabidiol has a distinct way of interacting with the endocannabinoid system that appears very promising for therapeutic applications with relation to inflammation.1 This article will serve as an easy-to-read synopsis of much of the research in this area regarding inflammation correlated with arthritis, Type 12 and 2 diabetes,3 atherosclerosis, Alzheimer’s,4 hypertension,5 metabolic syndrome,6 depression,7 and neuropathy.8

Studies On The Benefits CBD and Hemp For Inflammation

Throughout this article, I will cite specific research papers next to each claim, however I think it also may be helpful for some of you who are more interested in digging deeply into this body of research, to have a specific list of research papers regarding cannabidiol and inflammation that can give you a more thorough understanding of the subject.

There are definitely more papers out there, but this is my short list of recommended reading on the hemp and inflammation:

Hemp Extract, CBD and Pain:

Neuropathy is caused by microglia (the most common form of cellular immune defense) activation in the brain and spinal cord, which triggers the release of the cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα), which put into simple terms, are pro-inflammatory molecules.

The causes of neuropathic pain itself are poorly understood outside of this basic biological reaction. However, neuropathy pain is present in nearly all common forms of disease such as diabetes, cancer, autoimmune diseases, and MS.9

In a mouse model, CBD was demonstrated to alleviate heat sensitivity and allodynia (neuropathy pain) significantly.8

Two other studies demonstrated a very impressive calming of the immune system microglia/cytokine response along with promising anti-inflammatory improvements in patients with rheumatoid arthritis.910

CBD and Diabetes

By reducing insulin resistance and increasing insulin sensitivity, CBD was found in two separate research studies to reduce the initiation of diabetes and the development of latent diabetes in diabetes prone subjects.311 The super cool thing about this, is that this result was also accompanied by a shift from a pro-inflammatory cytokine response to an anti-inflammatory response.

Major effectors of β-cell death in type 1 diabetes are various free radicals and oxidant species, including NO, and infiltrating macrophages are one source of high concentrations of NO and inflammatory cytokines that further enhance NO and ROS formation.12

CBD oil has been shown in multiple studies to block ROS-induced up-regulation of surface adhesion molecules due to high blood glucose levels, which has preserved the barrier function of the endothelial cells,13 thus restricting those pesky free radicals and other oxidant species from infiltrating the β-cells.14

CBD To Help Depression and Anxiety

A large body of evidence in recent years has implicated this similar cytokine inflammatory response15 with depression in humans.16 The most convincing explanation is that the presence of excessive free radicals and oxidant species triggers the microglial cells to signal the release of the pro-inflammatory cytokines, which leads to depressive symptoms.

CBD has been reported to aid in calming this response in medical research.7

This study specifically assessed the anti-depressant and mood-elevating activity of CBD oil finding that its effect appeared to be dose dependent.17

This study posits that this anti-depressant effect of CBD oil is likely due to activation of 5-HT1A receptors in the brain.18

Cannabidiol and Anti-Pain Anti-Inflammation Applications

Research in this area of CBD and inflammation is quickly evolving, and many of these papers I’ve cited here have put forward some very interesting theories surrounding promising therapies for people with diseases characterized by inflammation response due to microglial cell activation and the resulting pro-inflammatory cytokine increase.

I think it’s very important to also identify the actual causes of this inflammatory trigger, however countless people across the world are now in this state of poor health due to their own poor decisions (both known and unknown). It may not be their fault, but now it becomes our responsibility to do something positive to help ourselves by first calming down our inflammation response using effective natural therapies, then next we need to identify the causes of our personal inflammation and get rid of those bad habits, whether they’re stress-related, nutrition-relation, or due to exposure to environmental toxins.

Stay strong in the good fight and keep educating yourselves! If you’re interested in learning about where to buy cbd I recommend checking out this popular page on our site: Where To Buy CBD Oil and Hemp Extract


Medical References

Booz G. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med. 2011;51(5):1054-1061. [PubMed]
Rajesh M, Mukhopadhyay P, Bátkai S, et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 2010;56(25):2115-2125. [PubMed]
Weiss L, Zeira M, Reich S, et al. Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity. 2006;39(2):143-151. [PubMed]
Izzo A, Borrelli F, Capasso R, Di M, Mechoulam R. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci. 2009;30(10):515-527. [PubMed]
Shi P, Diez-Freire C, Jun J, et al. Brain microglial cytokines in neurogenic hypertension. Hypertension. 2010;56(2):297-303. [PubMed]
Zuardi A. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev Bras Psiquiatr. 2008;30(3):271-280. [PubMed]
Pertwee R. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol. 2008;153(2):199-215. [PubMed]
Toth C, Jedrzejewski N, Ellis C, Frey W. Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain. Mol Pain. 2010;6:16. [PubMed]
Kim D, You B, Jo E, Han S, Simon M, Lee S. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A. 2010;107(33):14851-14856. [PubMed]
Malfait A, Gallily R, Sumariwalla P, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000;97(17):9561-9566. [PubMed]
Weiss L, Zeira M, Reich S, et al. Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuropharmacology. 2008;54(1):244-249. [PubMed]
Pacher P, Beckman J, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87(1):315-424. [PubMed]
Rajesh M, Mukhopadhyay P, Bátkai S, et al. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol Heart Circ Physiol. 2007;293(1):H610-9. [PubMed]
El-Remessy A, Al-Shabrawey M, Khalifa Y, Tsai N, Caldwell R, Liou G. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol. 2006;168(1):235-244. [PubMed]
Maes M, Galecki P, Chang Y, Berk M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):676-692. [PubMed]
Song C, Wang H. Cytokines mediated inflammation and decreased neurogenesis in animal models of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):760-768. [PubMed]
El-Alfy A, Ivey K, Robinson K, et al. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacol Biochem Behav. 2010;95(4):434-442. [PubMed]
Zanelati T, Biojone C, Moreira F, Guimarães F, Joca S. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 2010;159(1):122-128. [PubMed]

What Is CBD: Science And Benefits Of CBD Oil

CBD, or cannabidiol, is a compound that can be found in both hemp – often as one of the components of a good full spectrum hemp extract – or medical marijuana.

CBD oil has a ton of therapeutic benefits, many of which we will get into here today.

With the rise in popularity of CBD oil in the mainstream awareness, I think it’s important to educate my readers on the true research-backed benefits of CBD oil. This is especially important because there are very few reputable websites out there right now that are taking the time to educate people on the subject.

Most people don’t have the wherewithal to dig into the research around CBD, which I think can potentially be dangerous as it creates an environment where wives’ tales and urban myths can spread easily, masquerading as “truth.”

CBD Research Is Evolving Quickly

One of the coolest things about CBD is the fact that there is already a wide breadth of research around it, ranging from clinical trials evaluating therapeutic applications in humans, to in vitro studies, which are basically test tube experiments. There have also been a fair amount of animal studies, which can teach us a bit more about mammalian applications, and typically animal studies can correlate, with a fair degree of accuracy, to human effects. Researchers tend to use certain types of animals in research settings that have biological systems very similar to humans for this reason.

While CBD oil and cannabis in general has been widely marginalized in the United States for nearly 100 years, there is actually a surprising amount of positive research around the subject already, due to the rise in popularity and nearly unstoppable momentum behind the federal legalization of cannabis. It’s only a matter of time before the flood gates open on federal funding into the amazing therapeutic healing plant.

CBD Activates Endocannabinoid Receptors

You may be wondering about the physiological basis for the wide-reaching effectiveness of CBD in helping people with things like epilepsy,1 pain management,2 sleep,3 anxiety,4 depression,5 inflammation,6 cancer,7 addiction,8 and neuropathy.9

All throughout your brain and body are receptor sites.

These receptor sites are typically bound by endogenous (from within your body) neurotransmitters. Your cells communicate with one another using neurotransmitters, hormones, and second messengers. Certain messenger molecules fit into specific receptor sites. Many of these lie within the brain itself, but they’re also spread throughout the body in things like soft tissue, muscles, organs, and even bone.

CBD molecules can specifically bind to certain receptor sites within the endocannabinoid system (ECS), as well as other neurotransmitter systems. The ECS, however, when activated by CBD, indirectly through CB1 and CB2 receptor sites,10 (which is why it does not get you “high” like THC) has been linked to the myriad health benefits typically associated with CBD Oil. These CB1 and CB2 receptor sites can be found all throughout the brain and the body, but CBD also works outside of the ECS in other neurotransmitter systems, hence the wide ranging health benefits11 and applications of consuming a high quality CBD oil.

So what are some of these key benefits?

Let’s take a quick look at some of the current applications researchers are exploring for CBD benefits in humans and animals.

3 Major Benefits Of CBD Oil (Research and Therapeutic Applications)

1. CBD and Inflammation: The Anti-Inflammatory Benefits Of CBD Oil

Inflammation is caused chiefly by free radical stress on the body, which activates an immune response. The best way to fight it is to consume natural compounds that fight this free radical stress, such as potent anti-oxidants. I’ve discussed here on the blog about how Hemp Extract is rich in the potent antioxidant Vitamin E, but you’ll be happy to know that CBD itself can also act as an antioxidant in the fight against stress.

One of the ways CBD helps fight inflammation is through activation of glycine receptors,12 which has been shown to be a major target in chronic pain and inflammation treatments.

The anti-inflammatory effects of CBD are so potent, that they’ve even been shown to help alleviate neuropathy pain in MS patients.13

Even inflammation present in patients with Alzheimer’s Disease has been suppressed via CBD application in clinical research, due to the cannabidiol’s activation of PPARγ, which triggers the suppression of pro-inflammatory signaling.14

Irritable bowel syndrome (IBS) patients have also seen improvements in colon inflammation in research with use of CBD oil.15

2. CBD and Sleep: The Sleep Benefits Of CBD Oil

CBD oil has been studied quite a bit in reducing anxiety, as well as improving certain sleep biomarkers in humans. CBD oil may help increase overall amount of sleep time16 reduce insomnia, 17 and may even help with sleep onset and staying asleep in patients with chronic pain.18

3. CBD May Help Anxiety and Depression

Like I mentioned above, CBD oil has been demonstrated in research to help patients with anxiety issues. Most antioxidants, or stress-fighting natural compounds, act as anti-depressant agents in the body. I also mentioned earlier how CBD molecules can bind to glycine receptors, where glycine expression and glycine ratios in relation to other amino acids is considered a prime indicator of anti-depressant effects during major depression.19

Where To Buy CBD Oil

I personally think that it’s very important to get a high quality CBD oil, preferably organic, and extracted from hemp that is grown outdoors without pesticides or herbicides. If you search around on the internet right now, there are quite a few shady “companies” selling CBD oil, but most of it is CBD isolate, which has almost no benefits when compared to full spectrum extract.

I put together a helpful page called Where To Buy CBD Oil to hopefully point you in the right direction on getting some CBD from a high quality source.

Medical References

Devinsky O, Cilio M, Cross H, et al. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia. 2014;55(6):791-802. [PubMed]
Häuser W, Fitzcharles M, Radbruch L, Petzke F. Cannabinoids in Pain Management and Palliative Medicine. Dtsch Arztebl Int. 2017;114(38):627-634. [PubMed]
Rong C, Lee Y, Carmona N, et al. Cannabidiol in medical marijuana: Research vistas and potential opportunities. Pharmacol Res. 2017;121:213-218. [PubMed]
Lee J, Bertoglio L, Guimarães F, Stevenson C. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. Br J Pharmacol. 2017;174(19):3242-3256. [PubMed]
Campos A, Fogaça M, Scarante F, et al. Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders. Front Pharmacol. 2017;8:269. [PubMed]
Ryz N, Remillard D, Russo E. Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain. Cannabis Cannabinoid Res. 2017;2(1):210-216. [PubMed]
Soderstrom K, Soliman E, Van D. Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms. Front Pharmacol. 2017;8:720. [PubMed]
Shannon S, Opila-Lehman J. Cannabidiol Oil for Decreasing Addictive Use of Marijuana: A Case Report. Integr Med (Encinitas). 2015;14(6):31-35. [PubMed]
Blake A, Wan B, Malek L, et al. A selective review of medical cannabis in cancer pain management. Ann Palliat Med. August 2017. [PubMed]
Blázquez C, Chiarlone A, Bellocchio L, et al. The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. C. 2015;22(10):1618-1629. doi:10.1038/cdd.2015.11
Grotenhermen F, Müller-Vahl K. The therapeutic potential of cannabis and cannabinoids. Dtsch Arztebl Int. 2012;109(29-30):495-501. [PubMed]
Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. 2012;209(6):1121-1134. [PubMed]
Iskedjian M, Bereza B, Gordon A, Piwko C, Einarson T. Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain. Curr Med Res Opin. 2007;23(1):17-24. [PubMed]
Vallée A, Lecarpentier Y, Guillevin R, Vallée J. Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer’s disease. Acta Biochim Biophys Sin (Shanghai). 2017;49(10):853-866. [PubMed]
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What Is Hemp Extract? The Basic Science and Benefits Of Hemp

Hemp has been known widely for its industrial, environmental, and healing usages throughout history. One of the main distinguishing factors between hemp and marijuana, is the fact that hemp itself is non-psychoactive, meaning it will not get you “high” like marijuana will. This is chiefly due to the fact that while marijuana can contain between 5% to over 20% THC (tetrahydracannabinol) content, hemp typically only contains a measly 0.3% – 1.5%.1

Don’t worry though, the THC is not what makes hemp, and hemp extract so special.

In this article, we will cover the basics about the plant healing power behind hemp extract and why you may want to consider using hemp extract as a staple part of your daily health regimen, especially if you’re currently dealing with autoimmune issues, anxiety, depression, pain, or inflammation.

Industrial and Environmental Uses Of Hemp

While in this article we will be discussing the many health benefits of hemp extract, I also wanted to quickly give you a background of the other things hemp can be used for, since most people who are reading this blog article are likely exploring the subject and may be new to hemp.

Hemp is one of the strongest and most durable soft fibers grown on earth. It was outlawed in the US back in 1937 with the signing of the Marijuana Tax Act  – which was essentially an act of collusion between newspaper and timber magnate William Randolph Hearst and Federal Bureau of Narcotics chairman Harry Anslinger. If you’re interested in reading about the subject, I highly recommend the book The Marijuana Conviction, which outlines the entire ordeal in great detail. If you’ve ever wondered why cannabis has been illegal for our entire lifetime, despite so many amazing health benefits of both cannabis and hemp extract, then you’ll be absolutely surprised when you realize that its marginalization and demonization was entirely based on the threat hemp posed as a cash crop to timber in the US.

Hemp is a very useful alternative to not just traditional timber for paper products, but also to cotton as well. Just one acre of hemp can yield the same amount of fiber as 3 acres of cotton. This makes growing hemp very environmentally friendly, and useful for many things from clothing, to paper, to rope, and more.

Growing industrial hemp doesn’t require the use of any pesticides, or herbicides, and requires a fraction of the fertilizer needed for other cash crops. The ability to grow it without pesticides and herbicides obviously also translates to amazing health advantages for humans as well, especially since most of the produce and plant material we consume in the United States is grown on commercial farms and is doused in pesticides and other endocrine disrupting chemicals many times before it reaches our local grocery store shelves.

It makes a lot of sense, from the business perspective, why such an easy-to-grow, sustainable crop was seen as a massive threat to the big businessmen of the 1930’s namely William Randolph Hearst and Andrew Mellon, and why they worked so hard to defeat it and demonize it in the public eye. They were successful, but now the public is beginning to wake up.

The FARM Bill Of 2014 federally legalized the cultivation of industrial hemp in the US. According to the USDA:

“The term “industrial hemp” includes the plant Cannabis sativa L. and any part or derivative of such plant, including seeds of such plant, whether growing or not, that is used exclusively for industrial purposes (fiber and seed) with a tetrahydrocannabinols concentration of not more than 0.3 percent on a dry weight basis. The term “tetrahydrocannabinols” includes all isomers, acids, salts, and salts of isomers of tetrahydrocannabinols.”

This is taken from the Statement of Principles On Industrial Hemp provided by the Agriculture Department, the Drug Enforcement Agency, and the Food and Drug Administration on 08/12/2016.

And such, after that passed, there was an opportunity for farmers in the US to begin growing hemp on a large, and legal, scale. And also the opportunity to make an extract oil from the hemp seeds for health purposes.

What Is Hemp Oil Extract, CBD Oil?

Hemp extract is the oil that is extracted from the seeds of industrial hemp plants. Hemp oil extract typically contains high amounts of a compound known as CBD, or cannabidiol.2

CBD oil and full spectrum hemp oil extract have been widely clinically studied for use of pain management 3, epilepsy 4, stroke prevention 5, and joint health, 6 and even schizophrenia. 7

5 Health Benefits Of Hemp Extract

Hemp oil extract has a ton of health benefits for humans. I will have more articles on this website about all of the awesome benefits of this plant extract, but here are five benefits of hemp extract that may appeal to you.

If you would like to watch this in video format, I recommend viewing this video 5 Amazing Health Benefits Of Hemp Oil

1. Hemp Extract and Joint Pain:

One of the most widely known and appreciated benefits of hemp oil is how much it helps to alleviate joint pain, not just in men and women, but also in animals. Many people love to give it to their dogs and cats, especially since dogs and cats can develop arthritic joint pain as they age, which affects their mobility in the same way as aging humans.

One of the major reasons for the ability of cannabidiol and other phytocannabinoids in general to help regulate joint pain is the fact that CB1 and CB2 receptors (cannabinoid receptors) are expressed in joint tissues, neurons, chrondocytes, and bone. 8

Researchers have found alleviation of joint pain in both humans and animals via these CB1 and CB2 receptors, for example in osteoarthritis knee surgery patients. 9

2. Hemp Extract and Eczema:

Researchers have found a positive correlation between supplementation with hemp oil extract and improvements in a condition known as atopic dermatitis, otherwise known as eczema. 10 You can typically see benefits when using the extract topically, for example as a key ingredient in balms, creams, or lotions, as well as when you consume it orally.

3. Hemp Extract Helps Lower Blood Pressure:

Hemp extract has been shown in research to improve cardiovascular health in humans. 11 In a large study of 4680 individuals, promising results were shown in regulating blood pressure. 12 Other research has shown that the compounds in hemp extract can help decrease blood pressure in as little as 4 weeks of use. 1314

4. Hemp Oil Extract and Immunity:

The compounds in hemp oil have been positively correlated with an improvement in immune function in humans. 15

The presence of more endocannabinoids available for binding to your CB1 and CB2 receptors will decrease inflammation, strengthen the immune system, and keep the body healthy and strong.

5. Hemp Extract is Rich In Vitamin E:

Hemp is high in vitamin E.  Vitamin E is an extremely potent and helpful antioxidant, which also helps in the regulation of estrogen and the increase in the natural production of testosterone.

The different types of vitamin E include:

One of the main issues with consuming polyunsaturated fats, like the omega 3’s and omega 6s found in hemp oil, is that diets high in PUFAs can be hormonally damaging. However, hemp extract is amazing because it naturally negates the bad effects of its PUFA content because it is also rich in Vitamin E, which has been show to protect your body from the oxidative damage that you’d otherwise get from consuming the oil. 16

Both vitamin E and vitamin C have been shown in human research to slow the rate of free radical damage to the body.

Diets high in PUFAs requires increasingly higher amounts of Vitamin E if you want to regulate the free radical damage the PUFAs can do to your thyroid and pituitary, 17 however hemp oil extract is great because it naturally contains the right amount of Vitamin E to protect you from any amount of oil you consume.

Where To Buy Organic Hemp Extract

Hopefully this article was helpful in educating you about some of the awesome benefits of hemp oil and a bit of the background behind why it was initially banned in the United States but is now legal to grow again.

Hemp is an exciting new field of scientific study, agriculture, and health.

You may be curious at this point about where you can buy a good solid Hemp Extract from a reputable retailer. I put together a page with some details for you here: Where To Buy Hemp Extract


Medical References

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Schluttenhofer C, Yuan L. Challenges towards Revitalizing Hemp: A Multifaceted Crop. T. 2017;22(11):917-929. doi:10.1016/j.tplants.2017.08.004
Hill KP, Palastro MD, Johnson B, Ditre JW. Cannabis and Pain: A Clinical Review. C. 2017;2(1):96-104. doi:10.1089/can.2017.0017
Koo CM, Kang H-C. Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy? J. 2017;7(1):16-20. doi:10.14581/jer.17003
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